F2 populations of upland cotton (Gossypium hirsutum L.) are being bred for commercial production. The potential of F2's of Pima cotton (G. barbadense L.) has not been investigated. The present study was conducted to determine yield potential, boll and fiber properties, and yarn strength's of a group of F2's at low (below 750 m) and high (above 750 m) elevation environments in the Pima belt. Lint yield of 15 F2 populations ranged from 86 to 108% of Pima S-6 over three environments, with three F2's yielding significantly above PS-6. No F2 yielded significantly above midparent or high parent values but other parent combinations may give significant increase. A significant F2 X environment interaction for yield obtained; however, certain F2's were superior in yield across environments as indicated by their stability in ranking. The two highest yielding F2's also had longer stronger, and finer fiber with greater 22 count yarn strength compared with Pima S-6. These results indicate that F2 populations of Pima cotton warrant further investigation for enhancing yield potential and efficient production practices in the Pima belt.