Seedling diseases are a major problem for cotton producers in the USA. The complexity of pathogens and environmental factors associated with the seed-seedling disease complex confounds control measures. Cultural practices and a combination of fungicides must be used to control the array of pathogens that incite the disease complex, since most fungicides control specific or closely related pathogens. Combination of fungicides must be used as seed dressings and in-furrow applications. Recent development and subsequent use of the systemic fungicide, Apron, increased control of Pythium spp. Apron used in combination with other fungicides has increased the level of disease control obtained. Rhizoctonia solani, Pythium spp., and Thielaviopsis basicola occur beltwide and adversely affect plant stands and yield.