Continuous production of cotton on soils in the Mississippi Delta have resulted in reductions in organic matter and some increased compaction. With years of intensive cultivation of cotton, the productivity of some soils has declined. One method of enhancing productivity in other areas of the country has been the utilization of crop rotation system. Eight rotation systems involving cotton, corn and soybean were evaluated at Stoneville, Mississippi from 1983 through 1988 to determine the effects of the systems on yields of the crops grown in each system. Cotton following one or two years of corn produced significantly higher yields than continuous cotton. Corn yields following soybean were not significantly increased as expected and as had been observed in the Midwest. Rotations provide a means of potentially decreasing soil erosion and provide some means of soil conservation. Economic implications will provide the most impact on the adoption of sound rotation systems in the Mississippi Delta.