Missouri cotton producers frequently apply herbicides over-the-top of cotton and weeds because of the lack of rainfall for activation of soil applied herbicides. This practice is most often utilized when morningglories (Ipomoea sp.) emerge prior to or simultaneous with cotton. Post-directing cotton herbicides is impractical in these situations. Weed control, crop tolerance, cotton quality and yields were evaluated in 1987 and 1988 for postemergence treatments of 1 pt/A Cotoran (fluometuron) and 0.33 lb/A Probe (methazole). Cotoran and Probe were applied at three stages of cotton growth: 1) cotyledon, 2) early post (one true leaf), and 3) mid-post (five true leaves). All postemergence treatments followed 1.5 pt/A Treflan pre-plant incorporated and Cotoran preemergence at 2.5 pt/A. Cotoran provided 80% ivyleaf and entireleaf morningglory (Ipomeaomoea hederacea) and 70% velvetleaf (Abutilon theophrasti) control through 8 weeks after planting, regardless of the timing of application. Probe at all three application timings provided 70% morningglory and velvetleaf control and 80% common cocklebur control. Neither herbicide resulted in greater than 30% cotton injury at any of the application timings. Cotoran did not reduce seed cotton yields in 1987, however, yields were reduced 44% in treatments receiving Cotoran at the cotyledon stage of cotton in 1988. Seed cotton yields were reduced 16 to 50% in treatments receiving Probe over-the-top. Cotton quality was unaffected by either of these treatments.