Histologic and Morphometric Examination of Guinea Pig Lungs Following Subchronic Exposure to 1.6 Mg/m3 Cotton Dust 1182 DB

Beverly Y. Cockrell, Cheryl Rehfeld, Adeniyi Ogundiran, Ivy Vas, Carolyn Getty, Kathryn Spear, and Meryl H. Karol


 
ABSTRACT

Lungs of guinea pigs exposed subchronically to cotton dust at 1.6 mg/m3 were evaluated using histological and morphometric techniques. Histopathologic examination of lungs including major bronchi, numerous small bronchioles, trachea, nasal cavity and peribronchial lymph nodes, failed to reveal any notable difference between exposed and control guinea pigs. Using electron microscopy, increased numbers of alveolar macrophages and Type II cells were detected in exposed animals. Focal alveolar wall thickening was also observed. There was also significant slight thickening of bronchiolar smooth muscle. These changes were not of sufficient severity to have affected diffusion capacity.



Reprinted from Cotton Dust: Proceedings-12th Cotton Dust Research Conference 1988 pp. 161 - 162
©National Cotton Council, Memphis TN

[Main TOC] | [TOC] | [TOC by Section] | [Search] | [Help]
Previous Page [Previous] [Next] Next Page
 
Document last modified Sunday, Dec 6 1998