Typically harvested cottons were ginned using typical seed cotton cleaning and ginning equipment followed by minimum and elaborate lint cleaning at the gin and at the mill. The resulting cottons were spun into open-end yarns on the rotor system at commercial speeds and conditions. Yarn quality and spinning performance were measured to determine the effects of combinations of gin and mill cleaning conditions. Relationships between yarn quality spinning performance and the possibility of build-up of rotor deposits were studied for various combinations of gin and mill cleaning.