Soil salinity and its effect on crop yields is a serious problem in irrigated agriculture. Crop plants that are salt tolerant offer one approach to coping with salinity. The objectives of this research were to determine if salt tolerance during seed germination could be improved in American Pima cotton (Gossypium barbadense L.) and to evaluate the effects of selection pressure for salt tolerance on several agronomic and fiber quality traits. Seed of several Pima cotton genotypes were germinated in a range of NaCl solutions. Surviving seedlings from the highest salt levels were transplanted to the field where they were selfed and mass-crossed to produce seed for the next cycle of selection. The above procedure was repeated through three cycles of selection. Initially, Pima genotypes E14, P43, and Pima S-6 had 3, 5, and 10% germination, respectively, in a NaCl solution of -1.5 MPa osmotic potential. After three cycles of selection, these genotypes had 35, 51, and 40% germination, respectively, in a NaCl solution of -1.8 MPa osmotic potential. These results indicate that progress was made in increasing germination salt tolerance in Pima cotton. Effects of selection pressure for salt tolerance on agronomic and fiber quality traits were found to be minimal.