An experiment was conducted in Lufkin sandy loam soil on the Upland Farm at College Station. The objectives of this study were to quantify differences between multi-adversity resistant (MAR) and non-MAR cottons and within MAR cottons in drought resistance, and to determine the effect of water stress on cotton productivity and fiber quality. The experimental design was a split plot arrangement with irrigation treatments as whole plots and cultivars as subplots with five replications. The irrigated treatment received 5 supplemental irrigations totaling 15 inches of water from June 30 to July 30, with approximately 3-acre inches applied per irrigation. The non-irrigated treatment received less than 0.05 inches of rainfall during the supplemental irrigation period. Eight of the ten cultivars were from the MAR cotton program and represented different hybrid pools. The two non-MAR cultivars were Lankart 57 and Lockett