Human Platelet Activation: Synergism Between Cotton Bracts Tannin and Immunoglobulin

G Michael, S. Rohrbach, Rebecca A. Rolstad, and James A. Russell


Cotton bracts tannin and immunoglobulin C (IgG) act synergistically at low tannin concentrations to enhance the release of 5-hDroxytryptamine (5-HT) from human platelets. Augmentation of this reaction by the endotoxin from the rough mutant S. Minnesota R595 suggests that the enhanced release is due to the formation of tannin-IgG aggregates which function as platelet secretogogues.

Reprinted from Proceedings of the 1983 Beltwide Cotton Dust Conference pp. 29 - 31
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998