Fusarium and Verticillium wilts of cotton are widely distributed and cause great yield loss in China. Cotton seed- and soil-borne diseases and insect pests are also a serious problem in cotton production. Since 1951 47 Fusarium-wilt-resistant and Verticillium-wilt-resistant cultivars have been developed and grown in heavily infested regions. By means of an organic solvent infusion technique (OSI), fungicides such as carbendazim or ethylethene thiosulphonate penetrated dormant seeds, which increased the efficiency of disinfection of internal seed-borne pathogens. Seed coating treatment with different combined formulations of fungicides, insecticides and minor elements in various regions provided good integrated control of seed- and soilborne diseases as well as cotton aphids, thrips and soil insects at the seedling stage. Good plant development and increases in yield of lint cotton have been obtained in comparison with the untreated control in field tests.