Weeds present major problems for cotton culture. Studies were conducted in Riata cotton with glyphosate and sulfosate to evaluate control of field bindweed (Convolvulus arvensis), yellow nutsedge (Cypres exculentus), and redroot pigweed (Amaranthus retroflexus). Cotton injury related to timing and type of herbicides was also evaluated. Early broadcast applications of glyphosate or sulfosate provides good to excellent control of weeds. Sulfosate can produce major injury to the cotton. Later applications of glyphosate enhances weed control but adversely affects yield.