Field experiments were conducted to examine flumioxazin cotton injury and weed control. Flumioxazin was applied to 12- 14” cotton post-directed with eleven different nozzle types to determine if nozzle type affected cotton injury or weed control. Even flat-fan, drift guard flat fan, extended range flat fan, twin-jet flat fan, turbo flat fan, air-induction flat fan, low-pressure flat fan, and underleaf banded flat fan nozzles as well as flood and cone nozzles were examined. Flood jet nozzles tended to cause more injury early, but by 30 days after treatment no differences in weed control or injury were observed. In a separate study, cotton injury and weed control were examined from flumioxazin applied at 35 and 70 g/ha alone, tank-mixed with MSMA applied at 2.2 kg/ha or with glyphosate applied at 840 g/ha. As expected, weed control was better from the tank- mixes than with flumioxazin applied alone. However, in the tank mixes, weed control and subsequently cotton yield were equivalent between tank-mixes of MSMA or glyphosate with either the 35 or 70 g/ha rate of flumioxazin. Yields were reflective of cotton injury and weed control.