Field studies were conducted across the major cotton production regions in Texas to evaluate the effectiveness of Aim harvest aid in picker- and stripper-harvested systems. Aim was studied alone and in tankmix combinations with common harvest aid products. Results indicated that good coverage was essential. Rank plants were difficult to defoliate, leaving intact foliage on the lower third of the plant. Aim is a harsh compound compared to other defoliants, desiccating leaves in 2 to 4 days after application. The product has good activity on juvenile tissue and morninglory. Aim alone did not provide consistent results. However, Aim followed by a sequential application of Aim generally showed good results across locations. Generally, Aim did not provide regrowth suppression comparable to current standards. The current formulation (Aim 40DF) is very difficult to get into solution, which contributed to variable results.