On July 5^th, 2000, a federal registration was received from EPA on Intrepid for use in cotton. Commercial sales were initiated in 2001. Prior to the commercial registration , Section 18 Emergency Exemptions were granted for Intrepid (methoxyfenozide, RH-2485) insecticide in June of 2000 for control of the beet armyworm (Spodoptera exigua) on cotton (Gossypium spp.) in Arkansas, Louisiana, Mississippi and Texas. These exemptions allowed large scale aerial and ground experiments with Intrepid insecticide in cotton for control of the beet armyworm. In addition, data was also obtained with Intrepid insecticide for control of the soybean looper (Pseudoplusia includens) and saltmarsh caterpillar (Estigmene acrea). In May of 2001 an outbreak of saltmarsh caterpillar occurred in seedling cotton in the Mississippi Delta and Southeastern Arkansas. Data from both 2000 and 2001 indicated that Intrepid insecticide was not only highly effective for beet armyworms, but also provided highly effective control of soybean looper, cabbage looper and saltmarsh caterpillar with cessation of feeding occurring rapidly and mortality occurring in 2 to 5 days. Number of live worms and feeding damage was reduced with Intrepid applied at a rate range of 0.05 to 0.15 lb ai/acre in 5 gallons of water per acre by aerial application or 10 gallons of water per acre by ground equipment. Residual effectiveness on treated foliage with Intrepid was apparent for at least 14 days for beet armyworm, soybean looper and saltmarsh caterpillar.