Bollgard®II cotton was evaluated throughout the mid-South during the 2001 growing season. Systems trials were established using replicated, small plots of Bollgard®II, Bollgard® and conventional genotypes. Each genotype was scouted weekly and treated as needed for the control of lepidopteron pest. Unsprayed trials were established using large, 2-acre plots of Bollgard®II, Bollgard® and conventional genotypes, left untreated for lepidopteron pest. Scout reports indicate that under moderate bollworm pressure, Bollgard®II varieties suffered less square and boll damage due to the cotton bollworm (Helicoverpa zea) than Bollgard®varieties. Bollgard®II varieties left untreated for lepidopteron pest averaged 92 lb more lint per acre than Bollgard® varieties left untreated for lepidopteron pest. Beet Armyworm (Spodoptera exigua) data collected at one location indicated an average of 0.1, 9.6 and 10.2 larvae per meter of row in unsprayed Bollgard®II, Bollgard® and conventional genotypes respectively. Soybean looper (Pseudoplusia includens) data collected at the same location indicated an average of 0.4, 8.0 and 10.7 larvae per meter of row in unsprayed Bollgard®II, Bollgard® and conventional genotypes respectively. The data suggest that Bollgard®II is more effective against cotton bollworms, beet armyworms and soybean loopers than Bollgard®.