Reniform nematode infestations are becoming more widespread across the cottonbelt every year. Currently, there are no resistant commercial cultivars available to growers. In 2001, 28 entries were evaluated at the USDA-ARS North Farm reniform nematode nursery at Weslaco, TX. Average yield reduction between the fumigated and non-fumigated treatments was 27.8%. Six entries produced significantly higher lint yields than Stoneville 474 in the non-fumigated, reniform nematode infested plots. In the fumigated treatment, only N2387C and NX 2723ct produced significantly higher yields than Stoneville 474. Yield reduction between treatments were lowest for NX RN00513 (12.7%), DPL-SG215B/RR (13.2%), NX 2723ct (13.9%), and NX RN2126-1ctpc (14.2%). Yield reduction between treatments was highest for Phytogen PSC 355 (40.9%), NX C429-93-4ct (41.7%), and Fibermax 958 (44.5%). In general, Fibermax 832 produced the highest quality fiber. Results from the 2001 study indicate that germplasm with improved tolerance to reniform nematodes is being developed.