The importance of several factors of production on yield among cotton fields in North Carolina is examined. Data from 189 fields are used in the analysis. The log of yield was regressed on the log of: soil productivity, rainfall, pounds of active ingredient per acre for each of five variables, insecticide, herbicide, fungicide, growth regulator, and defoliant, pounds per acre each of nitrogen, phosphate, and potash, producer’s years of experience growing cotton and transgenic cotton. Dummy variables for seed type for herbicide resistant, insect resistant, and stacked varieties were included in the regression. The coefficients for herbicide and insecticide were positive and had p-values of less than 0.05. The coefficient for growth regulator was positive and had a p-value of 0.10. None of the other coefficients, including the seed type variables, were apparently different from zero at the 10 percent level of significance.