Recent commercialized developments in cotton production include genetic modification of the cotton plant for herbicide and insecticide resistance, variety improvements for increased yield and quality, improved equipment for on farm cottonseed treatment and new chemical molecules for cotton disease control. The newly registered triazole, strobilin and analine ester chemistries exhibit exceptional control and/or suppression of many cottonseed pathogens. Older chemistries such as TCMTB, 2-thiocyanomethylthiobenzothiazole, and chloroneb, 2-chloromethoxybezene possesses different modes of action as compared to the new chemistries, which allows disease resistant management strategies. Nucoat contains TCMTB and Chloroneb and was recently registered as a cottonseed hopperbox treatment. By combining different chemistries highly efficient and broad-spectrum disease resistant management programs can be prescribed on an as needed basis.