Producing cotton/ramie blended yarns and fabrics is an ideal way to integrate the best properties of both cotton and ramie fibers into a single textile product. However, the processing of cotton/ramie blends using a cotton system usually requires extra care. The spinning of cotton yarns blended with long stable ramie fiber requires special adjustment of the drawing frame so that adequate sliver and roving can be prepared prior to actual spinning. In this study, direct blending of cotton with ramie staple fiber was carried out prior to carding and drawing with the aim of minimizing equipment adjustment. Experimental cotton/ramie yarns of 20 Ne and 30 Ne, having a series of ramie blending ratios between 10% to 50%, were spun and then knitted into fabrics. Primary properties of the cotton/ramie blended fiber and yarns evaluated using the HVI and Uster tester. The Kawabata data were used to compare bending and compressive properties of the cotton/ramie blended fabrics with those of a pure cotton fabric of similar construction. The effect of the ramie blending ratio on blended yarn and fabric performance was analyzed and the optimal ramie blending ratio was determined.