Harvade 5F (dimethipin) was labeled for post-directed use in 1999 for broadleaf weed control in cotton (Parker et al., 2000), and has been evaluated across the cotton belt during 1999 and 2000. With the loss of Bladex ^® /Cy Pro ^® (cyanazine) as a standard post-directed and lay-by cotton herbicide treatment, Harvade 5F (dimethipin) has been evaluated in many tank mix combinations as a replacement. With outstanding activity on morningglory (Ipomoea sp.), sicklepod (Cassia obtusifolia), and other important broadleaf weed species, Harvade 5F is an excellent replacement for Bladex (cyanazine) in tank mixes for post-directed weed control in cotton.