Arizona cotton experienced a severe crisis in 1995 stemming from resistance of whiteflies to synergized pyrethroid insecticides. The insect growth regulators (IGRs), Knack® (pyriproxyfen) and Applaud® (buprofezin), served a pivotal role in resolving this problem. Similarly, Admire® (imidacloprid), the first neonicotinoid insecticide to obtain registration in Arizona, has been the foundation of whitefly control in vegetables and melons. In this paper we provide an update regarding the susceptibility to key insecticides of whiteflies from Arizona cotton, melons, and greenhouses. Overall, whitefly control in Arizona cotton remained excellent in the 2000 season and there were no reported field failures. However, there was a significant decrease in susceptibility to Applaud of whiteflies collected from cotton. One collection from Eloy, Arizona, in 2000 had susceptibility to Applaud that was reduced 129-fold relative to a reference strain. Whiteflies resistant to Knack, detected for the first time in Arizona in 1999, were again detected in 2000 but at lower frequencies than in 1999. Though whiteflies resistant to Admire/Provado® continued to be found at specific locations, overall susceptibility to Admire/Provado in 2000 remained high in whitefly collections from cotton. The new neonicotinoid insecticides, thiamethoxam and acetamiprid, were similar in toxicity to Arizona whiteflies in laboratory bioassays and we confirmed the significant but relatively low-order cross-resistance we previously reported between these neonicotinoids and Admire/Provado. Arizona whiteflies continued to be relatively susceptible to mixtures of Danitol® (fenpropathrin) and Orthene® (acephate). Factors that could undermine the current success of whitefly resistance management in Arizona are discussed. These include: 1) more severe resistance to IGRs in whiteflies from cotton, stemming from increased IGR use within and outside of cotton; 2) resistance of vegetable, melon and greenhouse whiteflies to the various formulations of imidacloprid (Admire, Provado, Merit®, Marathon®); 3) the imminent registration of new neonicotinoid active ingredients in cotton, greenhouses and other Arizona crops.