While utilizing cotton IPM practices, over 20 mid-south cotton varieties were examined across different growing conditions for yield and lint quality during 1999 and 2000. An early-season variety (DP20B) was the highest yielding variety for both years. Based on yield, these data indicate that many commercially available varieties differed significantly from one another while some varieties were discounted for high micronaire. Furthermore, transgenic Bt cotton varieties significantly out-yielded non-Bt varieties by 94 lb lint/A during 2000. It is hoped that this information will be useful to the cotton grower for future cultivar selections in the mid-south.