In field experiments, we determined the effects of a defoliant (Def) alone and in combination with insecticides - Karate (1x rate, 0.033 lbAI) and Guthion (0.5x rate, 0.125 lb AI) - on boll weevil mortality in relation to sex, weight, and fecundity. Def by itself exhibited a toxic effect on boll weevil. Def + Karate (1x rate) and Def + Guthion (0.5x rate) showed synergistic effects on weevil mortality. Boll weevil females seemed to be more tolerant to the chemicals and their mixtures than males. Weevils that died from chemical treatments weighed less than survivors. Oviposition was low both before and after treatment because most of the population appeared to be in or entering diapause. These preliminary results suggest that incorporation of an insecticide with the defoliant would permit growers to reap some benefits of a diapause control program at reduced cost (Robinson et al. 2001) and possibly with a reduced insecticide input into the environment.