Approximately seventy-five percent of Mississippi’s 1.28 million acres of cotton was planted to Bt-transgenic varieties in 2000. A field survey was conducted during late season to compare performance of Bt and non-Bt varieties. Bt fields sustained significantly less caterpillar induced boll damage, 1.96% vs 3.40%, and received significantly fewer foliar insecticide treatments for control of bollworm and tobacco budworm, 0.27 vs 2.44. Results of similar surveys conducted from 1996 through 1999 are summarized. During the first five years of its use in Mississippi, Bt cotton consistently received fewer foliar insecticide treatments while also sustaining less caterpillar induced boll damage than non-Bt cotton.