Timely foliar application of Calypso (thiacloprid) or Leverage (imidacloprid & cyfluthrin) against cotton aphid resulted in yield increases of at least 104 lbs. of lint per acre. Plots treated for cotton aphid had greater boll retention on nodes corresponding to the time of aphid infestation than did untreated plots. Results suggest that aphid levels below established thresholds may cause yield losses due to plant stress. Gaucho seed treatment and Temik in-furrow resulted in similar yield and early fruit retention.