Reports of cavitation, also known as Phomopsis boll dangle, Phomopsis boll rot, xylem cavitation, vascular cavitation, cotton blossom rot, or atypical boll shed, have increased in the Mid-South and Southeastern regions of the U.S. Cotton Belt since the mid-1990s. Cavitation describes a condition in which small bolls rapidly desiccate, become necrotic prior to the initiation and/or completion of the abscission process, and have an accompanying characteristic elongated scar that extends basipetally from the peduncle. The result is that these small bolls become adhered to the sympodium. The cause of cavitation is not known, although two hypotheses (physiological and pathological) have been reported. Levels of cavitation, expressed as the number of cavitated sites per plant at fruiting positions 1 and 2, were recorded, along with the number of bolls per plant at fruiting positions 1 and 2, and lint yield, when available, in 1999 and 2000 for 125 varieties planted in grower fields, university official variety trials, and Delta and Pine Land Company on-farm trials in Alabama, Florida, Georgia, Mississippi, North Carolina, and South Carolina. Overall, cavitation levels were higher in 2000 than in 1999. No association between cavitation level and lint yield or relative boll load was detected. While 25 varieties had cavitation levels significantly higher than zero, the lint yields of these varieties were not different from the lint yields of varieties for which cavitation levels were not statistically different from zero. These data suggest that, while cavitation warrants continued observation and monitoring, lint yields are not impacted by its occurrence, which supports data reported previously.