This research was conducted during 1998 and 1999 to determine the effects of different weed control and disease control regimes on cotton (DPL5415RR) seedling stands, stress and seed cotton yields. Four different weed control programs were evaluated: 1. A traditional full season program consisting of Treflan 4E PPI, 0.75 lb ai/A, Zorial Rapid 80 PPI, 0.75 lb ai/A, Cotoran 4L PRE, 1.5 lb ai/A, Zorial Rapid 80, PRE, 0.75 lb ai/A, Cotoran 4L, POST, 1.0 lb ai/A, MSMA 6E, Post, 1.5 lb ai/A, Cy-Pro 4E, LATE POST, 0.6 lb ai/A, and MSMA 6E, LATE POST, 1.5 lb ai/A. 2. A combination of Cotoran 4L PRE, 1.5 lb/A, Zorial Rapid 80 PRE, 1.5 lb/A and Roundup Ultra 4E POST, 1.0 lb ai/A. 3. A combination of Prowl 3.3 EC PRE, 0.75 lb ai/A, Staple 75 SP PRE, 0.047 lb ai/A and Roundup Ultra 4E, P0ST, 1.0 lb ai/A. 4. A program with Roundup Ultra 4E POST, 1.0 lb ai/A only. 5. The non chemical check in which weeds were controlled by hoeing as needed. The disease control programs consisted of 1. Seed treatment only. 2. Seed treatment and a Hopper-box treatment of Delta-Coat AD, 11.75 oz per CWT. 3. Seed treatment and an In-furrow applied fungicide treatment of Ridomil Gold PC 11G, 7 lb/A. Two disease pressure levels were established by inoculating the plots in-furrow at planting with Rhizoctonia solani and Pythium infested oats or panicum.