Fusarium wilt of cotton has become a significant problem for Australian cotton growers since it was first observed in the 1992/93 season. Australian races of the pathogen are unique and nematodes are not involved in the etiology of the disease. Cotton breeding programs have produced some cultivars with a degree of resistance to the pathogen. Summer flooding provided good control of fusarium wilt at two sites and crop rotation treatments, the retention of crop residues on the surface, the use of systemic induced resistance and the adoption of better farm hygiene were identified as potential components of an integrated disease management strategy. The use of more effective seed treatment fungicides, solarisation, biofumigation and biocontrol treatments is being investigated.