Research was conducted in 1999 at the Macon Ridge Research Station in Winnsboro LA on a Gigger silt loam soil (pH 6.0, OM 1.0%) to determine the effects of postemergence-directed (PDIR) applications of Permit (halosulfuron) with or without MSMA on cotton growth and yield. Experimental design was a randomized complete block with a factorial arrangement of Permit rates applied either with or without MSMA. PDIR applications of Permit at 0.188 (0.25 oz/A), 0.38 (0.5 oz/A), 0.56 (0.75 oz/A), or 0.75 (1.0 oz/A) oz ai/A with or without MSMA at 0.8 lb ai/A (1.0 pt/A) were made to DP 458 BRR cotton at the 4 to 5 node growth stage. A nontreated check was included for comparison. Nonionic surfactant at 0.25% v/v was included with all treatments. Herbicide treatments were applied in conjunction with cultivation on a 20 in band at 15 GPA. Each 6.67' x 35', 2 row plot, including the nontreated check, received cultivation at the time of herbicide application. Plots received no preemergence (PRE) herbicides at planting on May 19. Research was conducted in a relatively weed free area and weeds which did emerge were controlled by hand hoeing, cultivation, and a PDIR application of pyrithiobac (Staple) at 1.0 oz ai/A (1.2 oz/A) plus fluazifop (Fusilade 2000) at 0.188 lb ai/A (24 oz/A) in conjunction with cultivation. Parameters measured included plant height 6, 21, 48, and 77 days after treatment (DAT), total plant dry weight (1 m of row/plot) 33 DAT, node above white flower (NAWF) 45 DAT, and seedcotton yield. Data were subjected to contrast analysis.