Johnsongrass [Sorghum halepense (L.) Pers.] is a severe problem in many cotton (Gossypium hirsutum L.) growing regions in the southwestern U.S. Other broadleaf weeds, such as common lambsquarters (Chenopodium album L.), can also become a problem. The introduction of POST graminicides have made a substantial impact on grass weed control in cotton. It is often desirable to apply herbicides in a mixture in order to broaden the weed control spectrum and to reduce application trips across the field. Studies have been conducted to evaluate the activity of various POST broadleaf grass herbicides when applied in a mixture. Reduced grass control through antagonism often is a result of applying these combinations.