Transgenic crops provide producers with several new options to control perennial weeds. Producers on the Texas Southern High Plains use preplant incorporated and preemergence herbicides to control many annual weed species. However, these herbicides have little activity on perennial weeds such as silverleaf nightshade (Solanum elaeagnifolium), woollyleaf bursage (Ambrosia grayi), and field bindweed (Convolvulus arvensis). Traditional perennial weed management includes in-season spot-spraying, fall applications, or preplant applications. The use of Roundup Ultra (glyphosate) in Roundup Ready cotton and Buctril (bromoxynil) in BXN cotton provide new options to control many of these perennial weeds in-season. The objectives of this research are: 1) to evaluate Roundup Ultra and Buctril applied alone or in combination with cultivation for perennial weed control; 2) to determine effects of weed control systems on cotton yield and net economic returns; and 3) to evaluate perennial weed control after each season of treatments.