Roundup Ready^® cotton (Gossypium hirsutum L.) was introduced commercially in the United States in 1997. Since introduction, adoption has increased each year and in 1999 Roundup Ready cotton was planted on over 5 million acres. Tolerance trial research and commercial experience have demonstrated that Roundup Ready cotton tolerance to Roundup Ultra^® (glyphosate) applications is excellent. In 1999, cotton growers in the southeast reported concerns about misshapen bolls, boll rot, cavitation and hard lock bolls. After extensive field investigations, it was determined that these maladies are not related to transgenic varieties or application of Roundup Ultra to Roundup Ready cotton.