A series of three field experiments were conducted at nine locations in North Carolina from 1996 through 1999 to examine the role of soil-applied herbicides in Roundup Ready cotton weed management programs. All experiments were conducted in fields heavily infested with weeds. Species present at one or more of the locations included large crabgrass (Digitaria sanguinalis), broadleaf signalgrass (Brachiaria platyphylla), seedling johnsongrass (Sorghum halepense), mixtures of morningglory (Ipomoea) species, common cocklebur (Xanthium strumarium), sicklepod (Senna obtusifolia), common ragweed (Ambrosia artemisiifolia), smooth pigweed (Amaranthus hybridus), Palmer amaranth (Amaranthus palmeri), common lambsquarters (Chenopodium album), prickly sida (Sida spinosa), smooth groundcherry (Physalis subglabrata), and jimsonweed (Datura stramonium). Soil-applied herbicides included Treflan (trifluralin) preplant incorporated (PPI) + Cotoran (fluometuron) preemergence (PRE) in the first experiment, Prowl (pendimethalin) PPI + Cotoran PRE in the second experiment, and Command (clomazone), Cotoran, Prowl, Staple (pyrithiobac), Zorial (norflurazon), Command + Cotoran, Prowl + Cotoran, Prowl + Staple, Staple + Cotoran, and Zorial + Cotoran PRE in the third experiment. Soil-applied herbicides were applied at normal use rates.