Annual morningglories (Ipomea spp) are difficult to control with existing cultural and herbicide programs in cotton. The objectives of these studies in 1997 and 1999 were to evaluate: increasing rates of Staple (pyrithiobac), tank mixes of Staple with Urea-ammonin nitrate solution (32%N) "UAN", tank mixes of Staple with MSMA, increasing rates of Valor (flumioxazin), tank mixes of Valor with Roundup Ultra (glyphosate), and tank mixes of Valor with MSMA. In 1997 all rates of Staple + crop oil concentrate (Agridex) gave partial control of emerged annual morningglory. The addition of 5 gallons/A of UAN fertilizer to Staple increased control in all rates of Staple. UAN fertilizer alone gave some control. Cotton injury was slight for 14 days following treatments. The addition of UAN to Bladex (cyanazine) gave better control of annual morningglory than the Bladex + Agridex, however cotton injury increased. In 1999 Valor + Agridex gave excellent control of emerged annual morningglory, however cotton injury was severe almost killing most plants. The tank mixes of Valor + MSMA and Valor + Roundup Ultra also gave excellent control of annual morningglory. The addition of Roundup Ultra, the tank mixes of Roundup Ultra with Bladex and Goal (oxyfluorfen) also gave excellent control of annual morningglory.