Reflex was considered for potential use in cotton during its early development. However, in recent years Zeneca has expressed new interest in developing a cotton registration, and additional cotton research has been conducted since 1997. Reflex was tested in several typical small-plot weed science trials on a typical sandy loam cotton soil (Tiptonville fine sandy loam, 56% sand, 36% silt and 8% clay) and on a "watermelon type" sandy soil (Broseley sandy loam 72% sand, 10% silt and 8% clay). Soil applications have included pre plant incorporated (PPI) and preemergence surface (PRE) treatments at rates including 0.25, 0.375 and 0.5 lb ai/A. Control of ivy, entireleaf and pitted morningglory (Ipomoea hederacea and Ipomoea lacunosa) from projected use rates (0.25 to 0.375 lb ai/A) has ranged from 33 to 85% (mean of 49%) from PPI applications and 75 to 90% (mean of 82%) from PRE applications. Common cocklebur (Xanthium strumarium) control from projected use rates has ranged from 20 to 29% (mean of 29%) PPI and from 75 to 94% (mean of 85%) PRE. Control of Palmer amaranth (Amarantus palmeri) and Smooth pigweed (Amaranthus hybridus) has generally been 90% or greater. Specifically, projected use rates provided 88 to 100% (mean of 94%) pigweed control PPI and 98 to 100% (mean of 100%) control PRE.