Carfentrazone-ethyl (F8426) is a new chemistry discovered by FMC Corporation that is registered for use in corn and small grains as Aim^TM 40DF. The product is characterized by rapid burndown activity that offers other advantages such as a novel mode of action, no soil residual or carryover, and no systemic off-target potential. F8426 is non-selective on cotton, and research trials have shown significant activity in a post-directed or shielded spray use pattern for the control of key weeds with the product used alone or in an additive combination with other cotton postemergence herbicides. Development will continue to determine the optimum fit of F8426 in cotton postemergence weed control programs as well as in other cotton use patterns such as preplant burndown and defoliation.