Information on phosphorus (P₂O₅) and potassium (K₂O) nutrition for no-till (NT) cotton (Gossypium hirsutum L.) production is limited. Research was initiated in 1994 and continued through 1999 on a Loring silt loam at the Milan Experiment Station evaluating P₂O₅ and K₂O fertilization rates for conventional- (CT) and NT production systems. Initially, Mehlich I extractable P was low and extractable K was medium. The experimental design was a split plot, main plots were tillage and P2O5-K₂O rates sub-plots. The applied P₂O₅ rates were 0, 40, 80, and 120 lb/acre while the applied K₂O rates were 0, 30, and 60 lb/acre. Treatments were replicated four times. The ANOVA showed a tillage-by-P-K rate-by-year interaction effect on yields. Yearly CT and NT yields were increased by P₂O₅ fertilization. CT yields were increased by broadcasting 40 lb P₂O₅/acre four of the six years with 80 lb required the other two years. NT yields were increased by 40 lb P₂O₅/acre three of the six years with 80 and 120 needed the other three years.