Research has shown that topical applications of Roundup (glyphosate) to glyphosate-tolerant cotton (Gossypium hirsutum L.) cultivars may decrease early-season boll retention at first position sympodia; however, topical applications of glyphosate to transgenic cotton typically do not reduce lint yield. The loss of early season fruit can be tolerated in most years when growing conditions permit reproductive development to be extended later in the season.