Unique upland cotton germplasm is under development that shows out-standing tolerance to abiotic stresses. Several advanced generation pro-geny lines which resulted from interspecific crosses of selected individual plants of original upland (Deltapine 90) acala type cotton and extra long staple pima (Pima S-6) cultivars have exhibited transgressive traits of agronomic value. Foremost among the characteristics for which selection was undertaken were drought and heat stress tolerance. Initial early generation selections were based upon superior germination and stand establishment with little regard for lint yield or quality beyond reproduction of the line. Only the best half of the selections were advanced in each of the first two years of the tests. Promising crosses were made and their progeny were included in later evaluations, as reported in previous Beltwide Proceedings. (McDaniel and Dobrenz, 1994; McDaniel, 1997).