Costs for biotransgenic cottonseed have increased in recent years to levels of over $50/acre, making it one of the highest input costs to American cotton farmers. To understand the relationships among seeding rate, within-field geographical variation, and yield, the NASA Commercial Remote Sensing Program and ITD-Spectral Visions are working with Perthshire Farms in Gunnison, Mississippi to conduct an inductive experiment aimed at shedding light on this increasingly expensive input. This variable-rate seeding experiment revealed that plots seeded at a rate of 3 seeds/foot (39,000/acre) produced 2% to 10% more yield, saved 31% to 66% in seeding costs, and increased profit margins by 7% to 13%, when compared to seeding rates of 4 and 5 seeds/foot. The relationship between seeding rate and yield was then measured within a series of geographical zones derived from remote sensing and field data, to determine if certain geographic features would produce a higher yield at a particular seeding rate. While certain patterns did merge, the low seeding rate of 39,000 seeds/acre generally ranked as the most economical from the perspective of the grower, regardless of geography.