Growers from the north of México, particularly those in the state of Chihuahua are looking for crops with higher returns. Cotton should be the crop that could improve their returns via productivity. An interdisciplinary team conducted this study. Two transgenic cotton varieties: DP-33B, DP-90B and four non-transgenic cotton varieties: DP 5415, STONEVILLE 239, STONEVILLE 474, SURE GROW 125, FIBER MAX 963 were planted in Delicias, Chihuahua, Mexico. STONEVILLE 239, DP-90B, DP-33B, and SURE GROW were the outstanding yield varieties. The gross returns of STONEVILLE 239, DP-90B and DP-33B, and SURE GROW were higher by 55%, 54%, 51% and 44% than the gross returns of FIBER MAX 963. The promissory varietie for Delicias are STONEVILLE 239, DP-33B, DP-90B and SURE GROW 125.