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The Role Arachidonic Acid Metabolites in the Response of Guinea Pig Lung and Dermal Vasculature to Extracts of Cotton Dust

N.A. El-Mahdy, M.A.A. Nasra, W.M. Awara, T.A. ElMasry and P.J. Nicholls


 
ABSTRACT

The ability of cotton dust extract (CDE) to release Inflammatory mediators have been considered to play a role in the development of byssinosis. In this study, an experimental model of guinea pig lung perfusion has been employed to examine the effect of previous exposure to CDE on the pulmonary perfusion pressure (PPP) and to study the release and pulmonary activity of arachidonic acid (AA) metabolites. In addition, the possibility of CDE acting as a sensitizing agent has been examined using a cutaneous reaction test.

CDE produced a significant increase in both PPP and cutaneous vascular permeability. In addition prostaglandin (s) and leukotriene (s) were released by CDE and appeared to be responsible for the pharmacological responses recorded. Prior exposure of the animals to CDE increased the subsequent responses of lung and skin to CDE challenge and mediator release was enhanced.



Reprinted from Proceedings of the 1999 Beltwide Cotton Conferences pp. 206 - 212
©National Cotton Council, Memphis TN

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Document last modified Monday, Jun 21 1999