The National Institute for Occupational Safety and Health (NIOSH) has a long-standing initiative related to the safety and health of workers in agricultural occupations. In 1990, the Congress of the United States, under Public Law 101-517, directed NIOSH to develop a national program in agricultural safety and health. Congress extended the NIOSH mandate in 1997 to include efforts directed childhood agricultural health and safety issues. NIOSH, through extramural and intramural surveillance, research, education, and intervention, pursues a national program to prevent human disease, injuries and deaths in agriculture. The focus of this paper will be the partnerships that NIOSH forged with public an private institutions throughout the nation in an effort to accomplish this activity.