CGA-248757 (Action) is a new harvest-aid compound under development by Novartis. A field study was conducted in central Texas in 1998 to evaluate the effectiveness of Action as a harvest-aid for picker-harvested cotton. Action (fluthiacet-methyl) was studied alone and in tankmix combinations with other compounds. Products included in the study were Def (tribufos), Dropp (thiadiazuron), Finish (ethephon + cyclanilide), Ginstar (diuron + thiadiazuron), and Prep (ethephon). Action applied as a sequential treatment (2.02 g a.i./acre, followed by the same rate 5 days later) demonstrated more than 91% defoliation and was comparable to the standard, Dropp + Def treatment (92%). The higher rate sequential Action treatment (2.83 g) did not improve defoliation over the 2.02 g treatment. The singular Action treatments, regardless of tankmix partners were ineffective in providing adequate leaf drop for picker-harvest. All treatments showed less than 10% desiccation. Singular applications of Action did not provide terminal regrowth suppression (> 70%) comparable to the sequential Action treatments (< 30%).