In 1997, the Mexican production of cotton was 1% of the world production, but did not satisfy the domestic demand for cotton. Chihuahuan farmers are trying to increase cotton yield, quality, and the health of the environment. Therefore, an interdisciplinary team at Universidad Autonoma de Chihuahua conducted a study in Delicias, Chihuahua to analyze and compare four Tansgenic cotton varieties: DP-33B, DP-90B, DP-32B, DP-35B versus a conventional variety: DP-5690. The transgenic varieties had superior performance in yield.. The over seed cost of transgenic varieties was compensated by the lower cost of pest control. These varieties had higher returns to land and risk than the return to land and risk of the conventional variety. The variety DP-33B appears to be the promissory variety for Delicias, Chihuahua.