There are a number of management options for root-knot nematode in the San Joaquin Valley. These include chemical control using fumigants and contact pesticides and cultural controls such as crop rotation and host plant resistance. We evaluated two Acala cultivars in fumigated and unfumigated areas, with and without aldicarb. Best yields for susceptible Maxxa cotton were attained with fumigation but was not significantly better than resistant NemX. No significant yield increase was noted with the use of Temik. In 1995 and 1996, five one-year rotations were evaluated including blackeye bean (Vigna sinensis, CB88), alfalfa (Medicago sativa, WL 525 HQ), Acala cottons (Gossypium hirsutum, Maxxa and NemX) and Pima cotton (Gossypium barbendense, S7). Bean, alfalfa, and NemX cotton resulted in significant yield enhancement the subsequent year and reduced the population of root-knot nematode compared to susceptible Acala Maxxa and Pima cottons. When NemX is grown over multiple years, no additional benefit in reducing root-knot nematode population is seen over a single year.