Verticillium and Fusarium wilt diseases are a serious problem is many areas of the cottonbelt. Methods, including the multi-adversity resistance (MAR) cotton system, used in breeding for resistance to Verticillium and Fusarium wilts, genetics of resistance, screening for resistance, and progress in developing new MAR germplasm resistant to both wilts are discussed. Progressive improvements in resistance to wilt pathogens and nematodes are being made in the MAR germplasm even though no direct selection for these pathogens is practiced.