A two-year study was conducted in the Brazos Bottoms in 1996 and 1997 to test the effects of different rates of soil-applied AmiSorb® with varying nitrogen fertility treatments in cotton (Gossypium hirsutum). Nitrogen fertilizer rates consisted of 30, 90 and 150 lbs. N/acre applied as ammonium nitrate. In 1996, the fertilizer was applied as a side-dress to a nitrogen-deficient soil after planting and crop emergence. In 1997, the pre-plant fertilizer was knifed in before planting to a nitrogen-deficient soil. Rates of AmiSorb® applied were of 2, 4 and 8 qts./acre applied as a split application at fertilization and planting. All but one quart of the nutrient uptake enhancement material was applied in-furrow on top of the seed at planting. The other quart was applied at fertilization. Lint yields using 90 and 150 lbs. N/acre were greater than those from treatments with 30 lbs. N/acre. Yield, however, was unaffected by AmiSorb®.