Uniform and vigorous seedling establishment and early season growth are critical in reaching the full yield potential of a cotton crop. Unfavorable environmental conditions often exist during the optimum planting and early season growth periods, resulting in reduced stands and stunted plants. Thus, management practices that would help insure adequate stand establishment and vigorous growth under less than optimum conditions would be beneficial for cotton production. This study was conducted to evaluate the effects of seed applied Plant Growth Regulators (PGRs) on cotton germination, emergence, and early season growth. Nine commercially available materials (Arise, Cytoplex, Early Harvest, Maxon, PGR-IV, Pix, Ryzup, Stimulate, and Triggrr) were applied to seed at 0.5x, 1.0x, and 2.0x the recommended rates. In the field study, no significant increases in stand establishment were noted due to the PGR treatments when compared to the control in either 1996 or 1997. Ryzup increased plant height at the 1.0x and 2.0x rates, when measured at 14 days after planting, in 1996. Plant height was not significantly increased by the PGRs treatments in 1997 when compared to the control. Yield was not significantly increased by the PGR treatments in 1997. In the greenhouse study (1996), no significant differences in total root length or root dry weights were observed when compared to the control.