Fipronil (Regent® insecticide) was shown in a replicated field trial using ULV aerial application methods to be superior to malathion for boll weevil control as measured by leaf-disk bioassay and field observations. Such superiority was exhibited by higher weevil mortality and longer residual control in the bioassay and fewer boll weevil punctures in the field. Also, malathion caused a resurgence of aphids to a point where an aphicide application was necessary to prevent sticky cotton, while fipronil caused a decrease in aphid populations. There was little difference in beneficial populations between the two treatments, but this and other tests have shown that Orius sp. are relatively unharmed by fipronil.